Among the numerous confusions of type 2 diabetes but that advancement of cardiovascular sickness and more unfortunate clinical results following cardiovascular occasions but particularly coronary failures and might be of specific concern.
A recent study published in the journal DiabetesTrusted Source suggests that a lack of a specific molecule in red blood cells may be the root of type 2 diabetes-induced vascular complications.
In recent years, research has shown that these specialized cells undergo several changes and can become dysfunctional in people with this form of diabetes.
Changes in red blood cells 2 diabetes
Red blood cells carry oxygen from the lungs to the rest of the body.
This is partly achieved through the production of nitric oxide.
The body uses nitric oxide to widen blood vessels. And researchersTrusted Source have noted that red blood cells in people with type 2 diabetes have a reduced ability to produce nitric oxide. This can lead to the constriction of coronary arteries.
This is the primary molecule for storing and transferring energy within the body.
One more change in the red platelets of individuals with diabetes is an expanded arrangement of receptive oxygen species.
The presence of these molecules can lead to more plaque formation on the interior walls of arteries, a health problem called atherosclerosis.
In the new study, researchers at the Karolinska Institutet, in Sweden, investigated which molecular changes within red blood cells could explain these dysfunctions. The team recruited 36 participants with type 2 diabetes and 32 healthy participants who did not take medication and had normal fasting glucose levels and no history of cardiovascular disease.
The importance of microRNA-210
MicroRNA molecules occur naturally and regulate cellular functions, including vascular activity.
The study showed that the reduction in microRNA-210 caused changes in specific vascular protein levels.
These alterations contributed to the development of endothelial dysfunction.
The endothelium is the thin membrane that lines the heart and blood vessels.
no major influence on the detrimental effects of the changes to red blood cells in participants with type 2 diabetes.
Possible future treatment of 2 diabetes
Dr. Swapnil Khare, an assistant professor of clinical medicine and medical director of inpatient
diabetes at Indiana University School of Medicine, shared her thoughts on the study with Medical News Today.
“They showed in a part of the study that if they replace the microRNA, the endothelial dysfunction did improve,” Dr. Khare explained.
The direct relationship between microRNAs and red blood cells has yet to be completely understand.
The study authors acknowledge that clarifying the signaling pathways.
These biostructures which will require further examination
In an interview with MNT, Dr. Zhichao Zhou, a researcher at Karolinska Institutet and the first author of the study, said:
“Given [that] microRNAs are very stable in circulation in general, and [that] we observed that red blood cell microRNA-210 levels are decreased in type 2 diabetes,
microRNA-210 may become a potential diagnostic marker to predict possible vascular complications.”
In the conclusion to the study paper, the researchers write that increasing red blood cell microRNA-210 levels
has the potential to be an effective treatment for endothelial dysfunction and
help prevent vascular injury in people with type 2 diabetes.